Figure 5.

Prenatal immune activation increases methyl CpG-binding protein 2 (MeCP2) binding at the GAD1 and GAD2 promoter regions in the medial prefrontal cortex (mPFC) (A) MeCP2 binding at the GAD1 promoter. Left: the line plot shows MeCP2 binding at both promoter regions of interest (Region 1, R1; Region 2, R2) for the control (CON) and poly(I:C) (POL) offspring. Right: the bar plot shows the mean MeCP2 for both regions R1 and R2. *P < 0.05 as determined by a main effect of treatment arising in the repeated-measures ANOVA analysis. (B) MeCP2 binding at the GAD2 promoter. The bar plot shows the MeCP2 binding values in the region of interest in CON and POL offspring. **P < 0.01 as determined by a Student t-test. N(CON) = 7, N(POL) = 7. All values are means ± SEM.