Figure 6.

Significant correlations between behavioral performance and epigenetic markers at the GAD1 pre-TSS (transcriptional start site) promoter region in the medial prefrontal cortex (mPFC) of control (CON) and poly(I:C) (POL) offspring. Behavioral performance variables included in the analysis were the percent time spent in the novel arm in the Y-maze test and the delta time spent with mouse vs. dummy in the social interaction test. Epigenetic markers included in the analysis were 5-methylcytosine (5mC) binding or 5-hydroxymethylcytosine (5hmC) binding at the GAD1 pre-TSS promoter region. The correlations were performed using Pearson's product moment correlations. The regression lines represent the correlative analyses, r is the slope of the regression lines and P is the P-value. N = 16 (8 CON, 8 POL) for each correlation.