Table 1.

Correlation analyses between behavioral performance and epigenetic markers at the GAD1 (Regions 1 and 2) and GAD2 promoter regions in the medial prefrontal cortex (mPFC) of control (CON) and poly(I:C) (POL) offspring. Behavioral performance variables included in the analysis were the percent time spent in the novel arm in the Y-maze test and the delta time spent with mouse vs. dummy in the social interaction test. Epigenetic markers included in the analysis were 5-methylcytosine (5mC) binding, 5-hydroxymethylcytosine (5hmC) binding, and methyl CpG-binding protein 2 (MeCP2) binding at the GAD1 (regions 1 and 2) and GAD2 promoter regions. The correlations were performed using Pearson's product moment correlations. The coefficients of correlation r are given in the table for each correlative comparison.

GAD1 Promoter - Region 1	5mC enrichment	5hmC enrichment	MeCP2 enrichment
Working Memory Score	−0.51*	−0.57*	−0.14
Social Interaction Score	−0.51*	−0.55*	−0.62*
GAD1 Promoter - Region 2	5mC enrichment	5hmC enrichment	MeCP2 enrichment
Working Memory Score	−0.39	−0.48	−0.31
Social Interaction Score	−0.42	−0.50*	−0.65*
GAD2 Promoter	5mC enrichment	5hmC enrichment	MeCP2 enrichment
Working Memory Score	−0.25	−0.34	−0.44
Social Interaction Score	−0.44	−0.44	−0.35

*P < 0.05 signifies a significant Pearsons product correlation. N = 14-16 (7-8 CON, 7-8 POL) for each correlation.