Table 1.
Complete Blood Count and Serum Chemistries of Mice Treated for 7 Days With 10 mg/kg CFTRact-J027 or Vehicle Orally Once per Day
| Vehicle | CFTRact-J027 | P value | |
|---|---|---|---|
| Hemoglobin level, g/dL | 13.3 ± 0.2 | 12.8 ± 0.3 | >.05 |
| Leukocyte level, 103/μL | 1.9 ± 0.3 | 1.9 ± 0.5 | >.05 |
| Thrombocyte level, 103/μL | 790 ± 109 | 900 ± 48 | >.05 |
| Total protein level, g/dL | 4.7 ± 0.2 | 5.2 ± 0.1 | >.05 |
| Albumin level, g/dL | 2.6 ± 0.1 | 2.9 ± 0.03 | >.05 |
| Globulin level, g/dL | 2.1 ± 0.1 | 2.2 ± 0.1 | >.05 |
| ALT level, U/L | 52 ± 16 | 44 ± 6 | >.05 |
| AST level, U/L | 131 ± 17 | 105 ± 11 | >.05 |
| ALP level, U/L | 47 ± 8.5 | 53 ± 2.5 | >.05 |
| Total bilirubin level, mg/dL | 0.1 ± 0 | 0.1 ± 0 | >.05 |
| Glucose level, mg/dL | 156 ± 22 | 164 ± 6 | >.05 |
| Cholesterol level, mg/dL | 121 ± 14 | 121 ± 6 | >.05 |
| CK level, U/L | 344 ± 85 | 312 ± 62 | >.05 |
| Sodium level, mmol/L | 149 ± 2.3 | 151 ± 0.7 | >.05 |
| Potassium level, mmol/L | 5.0 ± 0.1 | 4.4 ± 0.1 | >.05 |
| Chloride level, mmol/L | 113 ± 1 | 115 ± 1 | >.05 |
| Calcium level, mg/dL | 8.5 ± 0.2 | 8.5 ± 0.04 | >.05 |
| Phosphorus level, mg/dL | 6.6 ± 0.9 | 6.8 ± 0.3 | >.05 |
| BUN level, mg/dL | 15.3 ± 3 | 18.4 ± 1.2 | >.05 |
| Creatinine level, mg/dL | 0.2 ± 0 | 0.2 ± 0 | >.05 |
| Bicarbonate level, mmol/L | 15.3 ± 1.6 | 16 ± 1.7 | >.05 |
NOTE. Mean ± SEM are shown, 5 mice per group. Student's t test was used.
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CK, creatinine kinase.