. Author manuscript; available in PMC: 2016 Apr 25.

Published in final edited form as: J Mol Genet Med. 2013 Dec 9;7(4):91. doi: 10.4172/1747-0862.1000091

Table 1.

Telomere integrity.

Target	Mechanism	Compound	Clinical Trial	Reference
Telomere DNA	inducing the formation of or stabilizing G-quadruplex	BRACO-19	No	43 (review)
		RHPS4	No	43 (review)
		Quarfloxin	Yes	44
Telomerase	hTR	Imetelstat	Yes	50, 66–69
	Inhibiting hTERT	AZT	approved for HIV	52, 53
	Inhibiting hTERT	BIBR1532	No	54–58
CST complex	Ctc1, Stn1, Ten1	N/A	N/A	N/A
Shelterins	blocking Pot1 binding to telo- meres stabilizing TRF2	SYSU-00692	No	68
Shelterins	blocking Pot1 binding to telo- meres stabilizing TRF2	Gemcitabine	approved for pancreatic cancer, breast can- cer, ovarian cancer, and lung cancer	69, 70
T-loop	destabilizing t-loop structure	t-oligos	No	73–83
Post-translational Modifications	TRF1-PARsylation	PARP inhibitor	Yes	88