Table 3.

Main results of RCTs evaluating the efficacy of vortioxetine in GAD

Study	Interventions	Response rates
		Odds ratios	95% confidence intervals	P-values	Z-score
Mahableshwarkar et al16	T: vortioxetine 2.5 mg/d	1.16	(0.84, 1.60)	0.38	0.89
Mahableshwarkar et al15	C: placebo
Mahableshwarkar et al16	T: vortioxetine 5 mg/d	1.41	(0.82, 2.41)	0.21	1.25
Bidzan et al18	C: placebo
Rothschild et al17
Mahableshwarkar et al16	T: vortioxetine 10 mg/d	1.05	(0.76, 1.46)	0.75	0.32
Mahableshwarkar et al15	C: placebo
Mahableshwarkar et al16	T: vortioxetine 2.5 mg/d	1.10	(0.80, 1.52)	0.57	0.57
Mahableshwarkar et al15	C: vortioxetine 10 mg/d

Abbreviations: GAD, generalized anxiety disorder; RCT, randomized control trial; T, treatment group; C, control group.