Table 4.

Adverse effects in the vortioxetine and placebo groups

Study	Group	No	Nausea	Dry mouth	Diarrhea	Constipation	Decreased appetite	Headache	Dizziness	Somnolence	Vomiting
Rothschild et al17	Vortioxetine	148	40	12	8	–	–	19	13	9	–
	Placebo	151	7	5	8	–	–	13	5	3	–
Mahableshwarkar et al16	Vortioxetine	156	26	14	9	10	2	18	13	7	5
	2.5 mg/d	155	45	17	11	4	5	20	9	13	5
	5 mg/d	156	53	21	20	12	5	25	14	8	9
	10 mg/d	155	27	10	9	6	3	20	5	6	6
	Placebo
Mahableshwarkar et al15	Vortioxetine	151	24	14	13	4	–	20	–	–	3
	2.5 mg/d	152	37	12	17	9	–	18	–	–	8
	10 mg/d	153	13	17	11	6	–	17	–	–	4
	Placebo
Bidzan et al18	Vortioxetine	150	19	–	–	–	–	18	10	–	–
	Placebo	150	10	–	–	–	–	14	5	–	–

Note: “–” represents that side effect was not assessed.