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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Horm Behav. 2015 Apr 14;76:136–142. doi: 10.1016/j.yhbeh.2015.04.001

Fig. 2.

Fig. 2

Disruption of CRF NMDAR1 (NR1) neurons significantly disrupts fear acquisition without effects on fear extinction retention. (A) CRF NR1 deficient mice (Cre+/fNR1+) show significantly enhanced fear acquisition and (B) fear retention compared to Cre−/fNR1+ mice with no significant difference during the (C) fear extinction test. A follow-up experiment infused CRF promoter driven lentivirus into the CeA of fNR1 mice resulting in disrupted CRF NR1 neurons only within the CeA. We again show significantly enhanced freezing behavior during (D) fear acquisition for mice with disruption of CRF NR1 neurons in the CeA (LV pCRF-Cre/fNR1+) compared to control virus infused mice (LV pGFP-Cre/fNR1+). LV pCRF-Cre/fNR1+ mice showed significantly enhanced (E) fear retention and (F) impaired fear extinction retention. Asterisk (*) indicates significant group difference.

Figures are adapted from Gafford et al. (2014).