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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Horm Behav. 2015 Apr 14;76:136–142. doi: 10.1016/j.yhbeh.2015.04.001

Fig. 3.

Fig. 3

Disruption of CRF GABAAα1 neurons has no effect on fear acquisition but significantly disrupts fear extinction. (A) CRF GABAAα1 deficient mice (Cre+/fGABAAα1) show no difference from Cre−/fGABAAα1 mice during fear conditioning or when tested for (B) fear retention. However, during the (C) fear extinction retention test they shown significant deficits. A follow-up experiment again shows no difference in freezing behavior during (D) fear acquisition or (E) fear retention for CRF GABAAα1 deficient mice (Cre+/fGABAAα1). However, Cre+/f GABAAα1 mice given a systemic infusion of a CRF receptor 1 antagonist (R121919) prior to fear extinction show a (E) partial rescue of fear extinction behavior during the (F) fear extinction retention test compared to vehicle injected controls. Asterisk (*) indicates significant group difference.

Figures are adapted from Gafford et al. (2012).