Table 2.

Effect of baseline obesity status on change in clinical outcomes at six months

Variable	Baseline			Estimated change from baseline			Estimated difference in 6-month change		Estimated difference in 6-month change(by sIPW)
	Overall	No obesity	Yes obesity	Overall	No obesity	Yes obesity	Yes – No		Yes – No
	Mean ± SD (N)	Mean ± SD (N)	Mean ± SD (N)	Mean [95%CI]	Mean [95%CI]	Mean [95%CI]	Mean [95%CI]	P	Mean [95%CI]	P
CGI-BP Severity	4.5 ± 0.9 (478)	4.6 ± 0.9 (266)	4.4 ± 0.8 (212)	−1.61 [−1.73, −1.50]	−1.70 [−1.85, −1.55]	−1.36 [−1.53, −1.18]	0.34 [0.12, 0.57]	0.003	0.35 [0.08, 0.61]	0.010
BISS total	56.1 ± 18.8 (478)	56.4 ± 18.1 (266)	55.8 ± 19.7 (212)	−28.39 [−30.18, −26.59]	−29.79 [−32.16, 27.41]	−25.55 [−28.26, −22.84]	4.24 [0.68, 7.80]	0.020	5.67[1.52, 9.82]	0.007
BISS depression	37.6 ± 14.1 (478)	37.7 ± 14.1 (266)	37.4 ± 14.1 (212)	−18.59 [−19.99, −17.20]	−20.08 [−21.93, 18.23]	−16.28 [−18.39, −14.18]	3.80 [1.03, 6.56]	0.007	4.66[1.45, 7.87]	0.005
BISS suicidality	0.7 ± 1.0 (478)	0.8 ± 1.1 (266)	0.6 ± 0.9 (212)	−0.41 [−0.50, −0.32]	−0.55 [−0.66, 0.43]	−0.27 [−0.41, −0.14]	0.27 [0.10, 0.45]	0.002	0.30[0.12, 0.48]	0.001
LIFE-RIFT total	14.2 ± 3.4 (472)	14.2 ± 3.4 (263)	14.3 ± 3.3 (209)	−3.62 [−4.02, −3.22]	−4.10 [−4.65, −3.55]	−2.97 [−3.60, −2.35]	1.13 [0.31, 1.95]	0.007	1.11 [0.17, 2.04]	0.021
Q-LES-Q overall	41.5 ± 24.6 (471)	40.6 ± 24.7 (262)	42.6 ± 24.5 (209)	20.09 [17.33, 22.85]	22.96 [19.15, 26.76]	16.95 [12.64, 21.26]	−6.01 [−11.68, −0.34]	0.038	−6.18[−12.44, 0.08]	0.053

Key: BISS = Bipolar Inventory of Symptoms Scale; CGI-BP Severity = Clinical Global Impression Severity Scale for Bipolar Disorder; CI = confidence interval; LIFE-RIFT = Life-Range of Impaired Functioning Tool; Q-LES-Q = Quality-of-Life Enjoyment and Satisfaction Questionnaire; sIPW = stabilized inverse probability weighting