Table 3.
Groups | Unstimulated | 24-h culture | 72-h culture | ||
---|---|---|---|---|---|
Medium alone | DSP30+rIL-2 | Medium alone | DSP30+rIL-2 | ||
% Ki67-positive cells | |||||
Low CTLA-4 expressors (n = 19) | 2.1 [0.3–4.5] | 2.2 [1.3–4.3] | 10.6 [3.8–28.8] | 1.5 [1.1–1.9] | 9.2 [4.0–21.6] |
High CTLA-4 expressors (n = 19) | 3.3 [1.6–3.6] | 2.3 [1.3–3.6] | 10.2 [2.5–15.1] | 2.2 [1.6–3.0] | 9.3 [5.9–12.0] |
Controls (n = 15) | 1.0 [0.0–2.8] | 0.0 [0.0–0.2] | 13.2 [10.2–15.0] | 0.4 [0.0–3.3] | 13.4 [11.3–17.5] |
Low vs high CTLA-4 expressors | NS | NS | NS | NS | NS |
Low CTLA-4 expressors vs controls | NS | NS | NS | NS | NS |
High CTLA-4 expressors vs controls | NS | NS | NS | NS | P = 0.05 |