Table 1.
Demographics and clinical characteristics
| DLB/S−a* | DLB/S+b* | |
|---|---|---|
| Male gender, n (%) | 6 (100) | 8 (67) |
| Age (years), median (range) | 72 (57 – 83) | 73 (56 – 80) |
| Disease duration (years), median (range) | 3.5 (1 – 8) | 3 (0 – 12) |
| MMSE score, median (range) | 22 (16 – 27) | 19 (10 – 29) |
| Hallucinations, n (%) | 5 (83) | 6 (50) |
| Cognitive fluctuations, n (%) | 3 (50) | 7 (87) (n = 8) |
| Signs of RBD, n (%) | 6 (100) | 6 (60) (n = 10) |
| Extrapyramidal signs, n (%) | 2 (33) | 10 (83) |
| Tremor | 2 (33) | 4 (33) |
| Rigidity | 1 (17) | 7 (58) |
| Bradykinesia | 2 (33) | 6 (50) |
| EEG abnormal, n (%) | 5 (83) | 9 (90) (n = 10) |
| MRI, n (%) | ||
| Temporal atrophy (MTA ≥2) | 1 (17) | 3 (25) |
| Global atrophy ≥2 | 0 | 2 (17) |
| Fazekas score ≥2 | 1 (17) | 2 (18) |
| CSF tau/Aβ42 ratio, median (range) | 0.32 (0.24 – 0.44) (n = 5) | 0.39 (0.19 – 0.49) (n = 4) |
| Follow-up MMSE score at 1 year, median (range) | 27 (23 – 28) (n = 5) | 22 (17 – 25) (n = 5) |
MMSE Mini Mental State examination, RBD REM sleep behaviour disorder, CSF cerebrospinal fluid, MTA medial temporal lobe atrophy score, MRI magnetic resonance imaging
aPatients with dementia with Lewy Bodies and a normal baseline [123I]FP-CIT SPECT scan; (n = 6, unless otherwise specified)
bPatients with dementia with Lewy bodies and an abnormal baseline [123I]FP-CIT SPECT; (n = 12, unless otherwise specified)
* no statistically significant differences were found, p-values>0.05