Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 21;7:11380. doi: 10.1038/ncomms11380

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) 2P image of a distal segment in an oblique branch. Spines s1–s4 were included in the LTP protocol; the reference spine did not receive LTP induction stimulus. (b) Somatic EPSPs by the five spines (s1–s4 (yellow circles) and reference spine (black circle)) in a, before (black) and >30 min after (red) delivering the LTP induction protocol to s1–s4 (inset shows LTP induction voltage trace). (c,d) Similar experiment as in a and b on a proximal segment in an oblique branch. (e) Time course of the effect of cooperative LTP protocol on somatic EPSP amplitude at s1–s4 in distal and proximal dendritic segments. (f) Summarized effect of the cooperative LTP protocol on peak somatic EPSP amplitude evoked in distal versus proximal segments in s1–s4 (distal (red), n=17 cells; proximal (blue), n=10 cells, grey circles represent averaged data from s1–s4 in individual experiments.) and in reference spines (distal (red), n=16; proximal (blue), n=8, grey circles represent individual spines). (g) Histogram of EPSP amplitude change in distal (red) and proximal (blue) s1–s4 spines. Note the normal distribution of the LTP effect in distal spines (Shapiro–Wilks test, P=0.120). Group data are presented as mean±s.e.m. ctr, control; Dist, distal; Prox, proximal; Ref, reference.