TABLE 2.

Comparison of the traditional TTTA to a 2-EIA TTTA and the C6 ELISA alone in sera from patients with well-characterized Lyme disease^a

Testing algorithm	Sensitivity (%)			Specificity (%)
	Stage 1 (n = 114)	Stage 2 (n = 26)	Stage 3 (n = 29)	Healthy donorsb (n = 1,246)	Patients with a non-LD infection or condition (n = 54)
Traditionalc	42.1	73.1	100	99.4	100
C6 ELISA alone	56.1	100	100	98.4	98.1
2-ELISAd	52.6	100	100	99.4	100

^aAdapted from reference 17.

^bData from healthy donors from regions in which Lyme disease is endemic and from those in which it is not endemic were combined.

^cTraditional TTTA, WCS ELISA followed by Western blot analysis.

^d2-ELISA, WCS ELISA followed by C6-ELISA.