TABLE 3.
Multinomial logistic regression analysis of antimicrobial nonsusceptibility among ST-217, ST-612, ST-8314, and ST-9067 of invasive serotype 1 pneumococcus, South Africa, 1989 to 2013
| Antimicrobial agenta | Resistance data by MLST (n)b |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ST-217C1 (353) |
ST-217C2 (15) |
ST-217C3 (14) |
ST-612 (168) |
ST-8314 (20) |
ST-9067 (28) |
|||||||
| No. (%) resistant | RRR (95% CI), P value | No. (%) resistant | RRR (95% CI), P value | No. (%) resistant | RRR (95% CI), P value | No. (%) resistant | RRR (95% CI), P value | No. (%) resistant | RRR (95% CI), P value | No. (%) resistant | RRR (95% CI), P value | |
| PEN | 2 (0.6) | Reference | 0 (0) | 0 (0) | 3 (2) | 3.192 (0.528–19), 0.206 | 3 (15) | 31 (5–198), <0.001 | 0 (0) | |||
| CHL | 1 (0.3) | Reference | 14 (93) | 4,928 (293–82,917), <0.001 | 4 (29) | 141 (14–1,376), <0.001 | 1 (0.6) | 2 (0.1321–34), 0.599 | 17 (85) | 1,995 (197–20,194), <0.001 | 0 (0) | |
| TET | 1 (0.3) | Reference | 15 (100) | 4,923 (293–82,766), <0.001 | 4 (29) | 141 (14–1,376), <0.001 | 2 (1) | 4 (0.382–47), 0.240 | 14 (70) | 821 (93–7,290), <0.001 | 0 (0) | |
| ERY | 0 (0) | Reference | 0 (0) | 0 (0) | 1 (0.6) | 1 (5) | 0 (0) | |||||
| CLI | 0 (0) | Reference | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |||||
| RIF | 2 (0.6) | Reference | 0 (0) | 0 (0) | 1 (0.6) | 1.051 (0.095–11), 0.967 | 0 (0) | 0 (0) | ||||
| TMP-SMX | 14 (4) | Reference | 14 (93) | 339 (42–2,757), <0.001 | 13 (93) | 315 (38–2,575), <0.001 | 6 (4) | 0.897 (0.338–2.377), 0.827 | 18 (90) | 218 (46–1,032), <0.001 | 0 (0) | |
a
PEN, penicillin; CHL, chloramphenicol; TET, tetracycline; ERY, erythromycin; CLI, clindamycin; RIF, rifampin; TMP-SMX, trimethoprim-sulfamethoxazole (co-trimoxazole).
b
RRR, relative risk ratio; 95% CI, 95% confidence interval.