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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Dev Dyn. 2016 Mar 14;245(5):547–557. doi: 10.1002/dvdy.24392

Figure 4. Foxa2 and VE cells distribution during notochord submergence.

Figure 4

A–E: FoxA2 (red) is expressed in the midline, node and gut endoderm of a headfold stage Afp-GFPTG/+ embryo labeling VE cells with GFP. Note the increased cell density and higher levels of FoxA2 expression in the midline and node.

F–I: At early somite (E-Som) stage, FoxA2 (in red) is still expressed in the midline, node and gut endoderm. VE cells are labeled with GFP. Note the FoxA2+ notochordal cells have submerged and VE cells from both side of the midline are now contiguous and recovering the notochordal plate.