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Homologous residues to at least one of Tyr185, Tyr 213 or Tyr214 are found in 81 of the 120 human SH2 domains. Gene products with both a kinase domain and a SH2 domain are 2.8 times more likely to have tyrosines phosphorylated at the equivalents of Tyr185, Tyr213 or Tyr214 than gene products with SH2 domains but without a kinase domain (18/22 (82%) compared with 17/59 (29%)).
