Table 2.
Patterns of treatment stratified by stage and histology.
| Squamous cell | Adenocarcinoma | Neuroendocrine | p-value | ||||
|---|---|---|---|---|---|---|---|
| N | (%) | N | (%) | N | (%) | ||
| Stage IA2–IIA | |||||||
| Primary treatment | <0.001 | ||||||
| Surgery | 23,131 | (72.5) | 9,494 | (82.9) | 373 | (69.1) | |
| Radiation | 5,624 | (17.6) | 1,217 | (10.6) | 121 | (22.4) | |
| No surgery or radiation | 738 | (2.3) | 224 | (2.0) | 18 | (3.3) | |
| Unknown | 2,410 | (7.6) | 512 | (4.5) | 28 | (5.2) | |
| Adjuvant therapy1 | |||||||
| Radiation | <0.001 | ||||||
| Combination | 2,390 | (10.3) | 726 | (7.7) | 36 | (9.7) | |
| External beam | 3,879 | (16.8) | 1,110 | (11.7) | 117 | (31.4) | |
| Brachytherapy | 1,051 | (4.5) | 347 | (3.7) | 18 | (4.8) | |
| None/unknown | 15,811 | (68.4) | 7,311 | (77.0) | 202 | (54.2) | |
| Chemotherapy1 | <0.001 | ||||||
| Yes | 4,194 | (18.1) | 1,222 | (12.9) | 272 | (72.9) | |
| No | 18,363 | (79.4) | 8,056 | (84.9) | 87 | (23.3) | |
| Unknown | 574 | (2.5) | 216 | (2.3) | 14 | (3.8) | |
| Stage IIB–IVA | |||||||
| Primary treatment | <0.001 | ||||||
| Surgery | 8,300 | (20.0) | 1,753 | (32.9) | 188 | (29.1) | |
| Radiation | 25,227 | (60.7) | 2,738 | (51.5) | 337 | (52.2) | |
| No treatment | 2,326 | (5.6) | 319 | (6.0) | 73 | (11.3) | |
| Unknown | 5,686 | (13.7) | 511 | (9.6) | 48 | (7.4) | |
| Concurrent chemotherapy2 | <0.001 | ||||||
| Yes | 19,909 | (78.9) | 2,077 | (75.9) | 301 | (89.3) | |
| No | 5,036 | (20.0) | 634 | (23.2) | 33 | (9.8) | |
| Unknown | 282 | (1.1) | 27 | (1.0) | 3 | (0.9) | |
| Stage IVB | |||||||
| Chemotherapy | 0.001 | ||||||
| Yes | 3,933 | (65.4) | 871 | (61.2) | 320 | (71.6) | |
| No | 1,924 | (32.0) | 504 | (35.4) | 116 | (26.0) | |
| Unknown | 160 | (2.7) | 49 | (3.4) | 11 | (2.5) | |
1
Among patients treated with primary surgery.
2
Among patients treated with primary radiotherapy.