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. Author manuscript; available in PMC: 2016 Apr 26.
Published in final edited form as: Biopharm Drug Dispos. 2016 Apr;37(3):123–141. doi: 10.1002/bdd.1996

Figure 4.

Figure 4

Effect of increased fup (2-fold) on CLh prediction for low to high extraction ratio (Eh) drugs. (Acids: red circle; Neutral: green circles; Bases: blue triangles; poorly cleared compounds with Eh < 0.25: closed symbols; highly cleared compounds with Eh > 0.25: open symbols). The fold-change in CLh was calculated with 2-fold increased fup. This fold-change in CLh is plotted against the Eh of the drug. The fold-change in CLh for low Eh compounds is proportional to increase in fup, whereas CLh for high Eh compounds is unaffected.