Table 4.
Association of perfusate biomarkers and pump parameters with 6-month eGFR
| Biomarker | Time Point (N) | Linear Regression Coefficient (95% confidence interval) | ||
|---|---|---|---|---|
| Unadjusted | Adjusted for donor variables only 1 | Adjusted for donor, transport & recipient variables 2 | ||
| Log NGAL | Base (668) | −0.23 (−1.32, 0.85) | −0.81 (−1.95, 0.33) | −0.68 (−1.78, 0.42) |
| Post (588) | −0.40 (−1.80, 1.00) | −1.45 (−2.98, 0.07) | −1.70 (−3.22, −0.18) | |
| Delta (588) | −0.35 (−1.44, 0.73) | −0.25 (−1.29, 0.79) | −0.58 (−1.62, 0.46) | |
| Log IL-18 | Base (661) | −0.11 (−2.23, 2.02) | −0.24 (−2.23, 1.74) | −0.15 (−2.06, 1.77) |
| Post (589) | −1.94 (−3.79, −0.09) | −1.76 (−3.61, 0.09) | −1.70 (−3.55, 0.15) | |
| Delta (582) | −1.91 (−3.66, −0.16) | −1.41 (−3.05, 0.24) | −1.62 (−3.27, 0.02) | |
| Log KIM-1 | Base (623) | −2.37 (−7.41, 2.66) | −1.89 (−6.78, 3.00) | −1.67 (−6.06, 2.72) |
| Post (588) | −0.94 (−3.14, 1.25) | −0.37 (−2.52, 1.78) | −0.38 (−2.67, 1.90) | |
| Delta (547) | −1.09 (−3.24, 1.06) | −0.36 (−2.40, 1.67) | −0.25 (−2.38, 1.87) | |
| Log L-FABP | Base (668) | −0.31 (−1.23, 0.60) | −0.56 (−1.41, 0.28) | −0.40 (−1.23, 0.43) |
| Post (589) | −1.65 (−2.87, −0.42) | −1.64 (−2.87, −0.40) | −1.48 (−2.69, −0.27) | |
| Delta (589) | −0.75 (−1.77, 0.28) | −0.35 (−1.44, 0.74) | −0.53 (−1.62, 0.55) | |
| Resistance, 0.1 mmHg/mL/min | 1 hr (640) | −1.61 (−2.80, −0.42) | −0.93 (−2.08, 0.21) | −1.11 (−2.25, 0.03) |
| 2 hr (592) | −2.76 (−4.79, −0.72) | −1.57 (−3.45, 0.31) | −1.63 (−3.45, 0.19) | |
| 4 hr (568) | −2.34 (−3.87, −0.81) | −1.06 (−2.32, 0.20) | −1.47 (−2.81, −0.14) | |
| 6 hr (515) | −3.81 (−5.96, −1.66) | −1.66 (−3.76, 0.44) | −2.48 (−4.55, −0.42) | |
| 8 hr (434) | −3.76 (−5.94, −1.58) | −2.01 (−4.17, 0.15) | −3.01 (−5.18, −0.83) | |
| Flow, 10 mL/min | 1 hr (640) | 0.89 (0.38, 1.41) | 0.63 (0.13, 1.13) | 0.71 (0.21, 1.20) |
| 2 hr (592) | 1.07 (0.49, 1.66) | 0.75 (0.19, 1.31) | 0.73 (0.18, 1.28) | |
| 4 hr (568) | 1.13 (0.51, 1.75) | 0.66 (0.08, 1.23) | 0.81 (0.25, 1.37) | |
| 6 hr (515) | 0.97 (0.30, 1.63) | 0.52 (−0.09, 1.12) | 0.65 (0.04, 1.27) | |
| 8 hr (432) | 1.18 (0.44, 1.91) | 0.86 (0.18, 1.55) | 0.94 (0.28, 1.59) | |
Perfusate biomarkers were log2-transformed. Biomarkers and pump parameters were added individually to all linear regression models (i.e., biomarkers were not combined during multivariable adjustment). Delta indicates log2(Post/Base). eGFR, estimated glomerular filtration rate; NGAL, neutrophil gelatinase-associated lipocalin; KIM-1, kidney injury molecule-1; L-FABP, liver fatty acid-binding protein. Values in parenthesis in represent number of observations for unadjusted model.
Donor variables used for adjustment: age, circulatory death (rather than brain death), black race, hypertension, diabetes, height, weight, stroke as cause of death, and terminal serum creatinine.
Includes all variables listed above plus the following transport and recipient variables: cold ischemia time, age, Black race, gender, previous kidney transplant, diabetes as the cause of end stage renal disease, number of human leukocyte antigen mismatches, body mass index, duration (vintage) of dialysis before transplant, and panel reactive antibody (%).