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. Author manuscript; available in PMC: 2016 Apr 26.
Published in final edited form as: Cell Metab. 2012 Apr 4;15(4):451–465. doi: 10.1016/j.cmet.2012.02.013

Figure 1. Constitutive impaired insulin-/IGF1-signaling induces mitochondrial metabolism, reduces ROS levels, and increases endogenous antioxidant defense in both C. elegans and murine embryonic fibroblasts.

Figure 1

(A–C) Survival on paraquat (D–F) ATP content, (G–I) oxygen consumption, (J–L) mitochondrial ROS levels, (N–O) hydrogen peroxide production, (P–R) superoxide dismutase activity, (S–U) catalase activity, each quantified in (A, D, G, J, M, P, S) daf-2(e1370) nematodes or (B, E, H, K, N, Q, T) IRS1−/− MEFs or (C, F, I, L, O, R, U) IR+/− MEFs (all depicted in black bars) relative to effects in the respective wild-type controls (white bars). All values are given as mean ± SD. *p<0.05, **p<0.01, ***p<0.001 versus respective controls.