Table 3.
Standardized Factor Loadings from the Final Bi-factor Model
| Overall Bi-Factor Model | Medication Free Bi-Factor Model | |||
|---|---|---|---|---|
| System Loadings | AL Loadings | System Loadings | AL Loadings | |
| SNS | Loading [95% CI] | Loading [95% CI] | Loading [95% CI] | Loading [95% CI] |
| E | 0.70*** [0.67, 0.74] | −0.27*** [−0.35, −0.18] | 0.70*** [0.64, 0.77] | −0.33*** [−0.47, −0.18] |
| NE | 0.70*** [0.66, 0.73] | 0.14** [0.05, 0.22] | 0.71*** [0.65, 0.76] | 0.10 [−0.04, 0.25] |
| PNS | ||||
| SDRR | −0.93*** [−0.96, −0.91] | −0.20*** [−0.28, −0.12] | −0.94*** [−0.98, −0.91] | −0.12 [−0.27, 0.03] |
| RMSSD | −0.81*** [−0.84, −0.79] | −0.11* [−0.19, −0.02] | −0.81*** [−0.85, −0.78] | −0.08 [−0.22, 0.05] |
| LFHRV | −0.76*** [−0.79, −0.73] | −0.23*** [−0.31, −0.15] | −0.77*** [−0.82, −0.72] | −0.15* [−0.27, −0.02] |
| HFHRV | −0.76*** [−0.79, −0.73] | −0.11** [−0.19, −0.03] | −0.76*** [−0.80, −0.71] | −0.05 [−0.18, 0.08] |
| Pulse Rate | 0.32*** [0.26, 0.37] | 0.36*** [0.29, 0.43] | 0.36*** [0.27, 0.45] | 0.40*** [0.28, 0.52] |
| HPA | ||||
| Cortisol | 0.31*** [0.21, 0.40] | −0.31*** [−0.39, −0.23] | 0.21 [−0.02, 0.44] | −0.22*** [−0.35, −0.08] |
| DHEA-S | 0.30*** [0.21, 0.39] | −0.06 [−0.13, 0.01] | 0.22 [−0.01, 0.45] | −0.00 [−0.11, 0.11] |
| Inflammation | ||||
| CRP | 0.55*** [0.45, 0.65] | 0.55*** [0.48, 0.62] | 0.55*** [0.32, 0.77] | 0.59*** [0.46, 0.73] |
| IL6 | 0.39*** [0.30, 0.48] | 0.53*** [0.45, 0.60] | 0.32*** [0.17, 0.47] | 0.59*** [0.48, 0.71] |
| Fibrinogen | 0.56*** [0.46, 0.66] | 0.37*** [0.29, 0.45] | 0.59*** [0.42, 0.76] | 0.36*** [0.23, 0.49] |
| sE-Selectin | −0.01 [−0.10, 0.09] | 0.37*** [0.30, 0.44] | −0.08 [−0.23, 0.06] | 0.33*** [0.21, 0.44] |
| sICAM-1 | 0.09 [−0.01, 0.20] | 0.24*** [0.16, 0.32] | 0.16 [−0.00, 0.32] | 0.23*** [0.10, 0.37] |
| Cardiovascular | ||||
| Pulse Pressure | 0.83*** [0.80, 0.86] | 0.09* [0.02, 0.16] | 0.86*** [0.80, 0.91] | 0.23*** [0.11, 0.35] |
| SBP | 0.83*** [0.80, 0.85] | 0.12** [0.04, 0.20] | 0.75*** [0.70, 0.79] | 0.30*** [0.18, 0.41] |
| Glucose | ||||
| Glucose | 0.90*** [0.86, 0.94] | 0.41*** [0.32, 0.50] | 0.90*** [0.84, 0.95] | 0.39*** [0.26, 0.52] |
| HbA1c | 0.60*** [0.52, 0.68] | 0.38*** [0.30, 0.46] | 0.50*** [0.37, 0.63] | 0.31*** [0.19, 0.42] |
| HOMA-IR | 0.28*** [0.20, 0.35] | 0.65*** [0.57, 0.73] | 0.25*** [0.16, 0.33] | 0.65*** [0.51, 0.79] |
| Lipids | ||||
| HOMA-IR† | 0.27*** [0.14, 0.39] | 0.37*** [0.21, 0.53] | ||
| WHR | 0.14* [0.03, 0.24] | 0.43*** [0.37, 0.49] | 0.20* [0.04, 0.35] | 0.38*** [0.27, 0.49] |
| HDL | −0.45*** [−0.58, −0.32] | −0.32*** [−0.42, −0.22] | −0.56*** [−0.72, −0.40] | −0.26** [−0.45, −0.06] |
| LDL | 0.26*** [0.19, 0.34] | 0.01 [−0.08, 0.11] | 0.39*** [0.27, 0.50] | 0.09 [−0.06, 0.25] |
| Triglycerides | 0.73*** [0.60, 0.86] | 0.37*** [0.25, 0.49] | 0.67*** [0.54, 0.80] | 0.31*** [0.13, 0.49] |
Note. System and AL denote the loadings of each biomarker on the specific system factor or on the common allostatic load factor. Standardized loadings are presented for all models. N = 1,254 for the overall bi-factor models, and N = 486 for the medication free bi-factor model.
†
cross-loading of HOMA-IR on Lipids system.
***
p < .001,
**
p < .01,
*
p < .05