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Perk ablation increases internodal length in vivo. (a) Osmicated teased fibers from WT, Perk+/−, S63del, and S63del//Perk+/− P20 femoral quadriceps nerves. Arrowheads, nodes of Ranvier; n, Schwann cell nuclei. Bar: 100 microns. (b) Quantification of internodal lengths at P10, P20, and P30. Error bars, SEM; **p < .01; ***p < .001; ns, not significant, one-way ANOVA; n = 111 to 182 internodes from at least three animals per genotype.
