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. 2016 Feb 26;39(4):322–329. doi: 10.14348/molcells.2016.2292

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Fig. 2. — Both Ca_V2.2 and Ca_V2.3 currents are suppressed by M₁R activation after full-activation of PKC. Phorbol 12-myristate 13-acetate (PMA, 1 μM) was applied for 2 min in tsA201 cells expressing M₁R and either Ca_V2.2 or Ca_V2.3 channels. Oxo-M was applied for 60 s in the presence of PMA. Normalized current regulation of (A) Ca_V2.2 channels (n = 9) and (B) Ca_V2.3 channels (n = 5) by M₁R stimulation. (C) Summary of % inhibition by Oxo-M of Ca_V2.2 (n = 9) and Ca_V2.3 (n = 5) currents. (D) The time constant for Oxo-M-induced inhibition of Ca_V2.2 (n = 9) and Ca_V2.3 (n = 5) currents. Data are mean ± SEM.