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. 2016 Apr 26;6:25039. doi: 10.1038/srep25039

Figure 4. Identification of candidate regulators of BT piRNA clusters.

Figure 4

(a) Expression profile of Mybl1. (b) Diagram depicting the first possible scenarios in which BT clusters are expressed due to an activator TF. (c) Similar to (b) but for second scenario, in which non-BT clusters are silenced in adult brain due to a repressor TF. (d) Expression profile of candidate TFs that fit first scenario. (e) Expression profile of candidate TFs that fit the second scenario. (f) Co-expression network obtained from GeneMANIA63 showing that many candidates co-express with Mybl1; TFs were classified as activator or a repressor based on our suggested scenarios as their assumed function in the scenarios does not contradict with known literature about their function.