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. 2016 Apr 26;6:25153. doi: 10.1038/srep25153

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Copyright © 2016, Macmillan Publishers Limited

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Mitochondria and different forms of EB1 and EB2 diffused in cytoplasm are shown. In response to mitochondrial damage, Parkin was recruited by PINK1 on OMM. Subsequently, heterodimers in the cytoplasm aggregated into foci and fused with the EB1 positive phagophore to induce mitochondria sequestration. Without heterodimerization, homodimers aggregated into more foci to compensate for loss of heterodimers, but mitochondria sequestration and IMM degradation were significantly limited.