Figure 5. Wire-QuIC reaction can be useful to evaluate the decontamination rate of human prions.

Decontamination of human sCJD prion with NaOH or SDS were evaluated by wire-QuIC reactions. Dilutions of sCJD-BH (10-fold) were attached to wires and then were treated with 1 mol/L of NaOH solution for 2 h (b) or 3% (w/v) SDS solution at 100 °C for 10 min (c). Wire-QuIC reactions were performed to measure the residual prion seeds to evaluate the decontamination rates of prion.