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. 2016 Apr 26;7:111. doi: 10.3389/fphar.2016.00111

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Copyright © 2016 Benson, Eadon, Desta, Liu, Lin, Burgess, Segar, Gaedigk and Skaar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The significant correlations between the expression of drug metabolism genes and clinically relevant transporter genes that are regulated by rifampin. The expression [represented by log2fold change (Log2FC)] after rifampin treatment was correlated between all CYP and 410 transporters genes. The figure illustrates, the seven significant positive and one significant negative correlations between the expression of CYP and drug transporter genes that were regulated by rifampin with an FDR < 0.05. These were the only correlations with a p < 0.05 by Spearman correlation. Spearman correlation was performed because an assumption of normal distribution could not be made.