Table 3.

All clinically relevant drug transporters correlated with miRNA induced by rifampin with a p < 0.05.

miRNA	Gene	Spearman correlation	p-value	miRNA	Gene	Spearman correlation	p-value
Positive correlation				Negative correlation
hsa-miR-200b#	SLCO1B1	0.96	0.0028	hsa-miR-107	SLC16A1	−0.96	0.0028
hsa-miR-766	ABCG2	0.96	0.0028	hsa-miR-202	SLC22A9	−0.93	0.0067
hsa-miR-660	ABCB11	0.96	0.0028	hsa-miR-616	SLC22A5	−0.93	0.0067
hsa-miR-660	ABCC6	0.93	0.0067	hsa-miR-95	ABCB11	−0.93	0.0067
hsa-miR-616	ABCC5	0.89	0.012	hsa-miR-335	ABCC4	−0.93	0.0067
hsa-miR-886-3p	SLC51B	0.89	0.012	hsa-miR-320	ABCC5	−0.89	0.012
hsa-miR-886-3p	SLC51A	0.89	0.012	hsa-miR-638	ABCC5	−0.86	0.024
hsa-miR-766	SLCO1B1	0.86	0.024	hsa-miR-186	SLC29A2	−0.86	0.024
hsa-miR-660	SLC47A1	0.86	0.024	hsa-miR-92a	ABCC4	−0.83	0.021
hsa-miR-335	SLC29A2	0.86	0.024	hsa-miR-320	ABCB11	−0.82	0.034
hsa-miR-107	SLC22A7	0.82	0.034	hsa-miR-616	SLCO1B1	−0.79	0.048
hsa-miR-660	SLCO2B1	0.82	0.034	hsa-miR-30d#	SLC29A1	−0.79	0.048
hsa-miR-660	SLCO4C1	0.82	0.034	hsa-miR-95	SLC47A1	−0.79	0.048
hsa-let-7g	SLC51A	0.82	0.034	hsa-miR-92a	SLCO1B3	−0.76	0.049
hsa-miR-766	SLCO2B1	0.79	0.048
hsa-miR-660	ABCC2	0.79	0.048
hsa-miR-660	SLC22A1	0.79	0.048

Correlation was assessed for all miRNA tested and the 410 transporters expressed in hepatocytes. Shown in this table are the all the clinically relevant drug transporters regardless of rifampin regulation with the miRNAs induced by rifampin with a p < 0.05. In bold, the subset of the only clinically relevant transporters whose expression was regulated by rifampin with an FDR < 0.05 and correlated with rifampin induced miRNAs. Spearman correlation selected as samples because assumption of normal distribution could not be made.