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. 2016 Apr 26;6:24867. doi: 10.1038/srep24867

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Copyright © 2016, Macmillan Publishers Limited

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(A) Representative histopathology for different organs in mice treated with and without VE-DC/siRNA for 24 h by hematoxylin-eosin staining (H-E). Blank scale bars = 200 μm. (B) Blood samples were drawn from orbit in mice treated with and without VE-DC/siRNA for 24 h and WBC levels were assessed. Values shown are means ± SD (n = 8/each group). (C) RBC from mice treated with and without VE-DC/siRNA was assessed Values shown are means ± SD (n = 8/each group). (D) Platelets from mice treated with and without VE-DC/siRNA were assessed. Values shown are means ± SD (n = 8/each group). (E) Total protein levels from mice treated with and without VE-DC/siRNA were assessed. Values shown are means ± SD (n = 8/each group). (F) ALT levels from mice treated with and without VE-DC/siRNA were assessed. Values shown are means ± SD (n = 8). (G) Creatinine levels from mice treated with and without VE-DC/siRNA were assessed. Values shown are means ± SD (n = 8/each group). (H) BUN levels from mice treated with and without VE-DC/siRNA were assessed. Values shown are means ± SD (n = 8/each group). (I) ELISA analysis for serum IFN-a level derived from mice treated with and without VE-DC/siRNA for 3 h. Values shown are means ± SD (n = 5/each group). (J) Real-time PCR analysis of IFN-β gene expression from mice (n = 5/each group) treated with and without VE-DC/siRNA for 3 h.