Table 1:
Selected laboratory data at key time points.
| Presentation (Weeks 0–12) | Prior to G-CSF initiation (Weeks 260–269) | After G-CSF initiation (Weeks 270–305) | |
|---|---|---|---|
| Hb (g/l) | 138–147 | 120–129 | 81–125 |
| MCV (FL) (80–99) | 97–10 | 108–116 | 86–111 |
| WBC (×109/l) | 2.3–3.3 | 1.4–3.2 | 1.1–11.2 |
| Neutrophils (×109/l) | 1.0–1.5 | 0.2–0.5 | 0.3–8.8 |
| Lymphocytes (×109/l) | 0.9–1.3 | 0.5–2.0 | 0.1–2.0 |
| Eosinophils (×109/l) | 0 | 0 | 0–0.1 |
| Platelets (×109/l) | 153–201 | 85–124 | 56–149 |
| Prothrombin time (INR 0.8–1.2) | 0.9 | – | 1.0–1.4 |
| CRP (mg/l) | 9–10 | <3 | 7–201 |
| Creatinine (μmol/l) | 84–96 | 67–84 | 48–116 |
| Serology for hepatitis A, B, C and HIV | Negative | – | Negative |
| EBV DNA (copies/ml) | – | – | <500 |
| Cerebrospinal fluid cells | No cells | ||
| Cerebrospinal fluid protein (0.15–0.45 g/l) | – | – | Protein 0.62 |
| Creatine kinase (24–195 U/l) | 69 | – | 30–39 |
| Ferritin (18–360 μg/l) | 343–437 | – | 1330–2339 |
| Vitamin B12 (200–900 ng/l) | 267 | 231 | 310 |
| Folate (4–18 μg/l) | 7.6 | 6.8 | 5.4 |
| Lactate dehydrogenase (135–225 U/l) | Normal | Normal | 231–290 |
| Immunoglobulins | |||
| IgG (6.0–16.0 g/l) | 10.2–11.8 | 10.9 | |
| IgA (0.8–4.0 g/l) | 3.8–5.6 | 4.0 | |
| IgM (0.5–2.0 g/l) | 1.8–6.3 | 1.7 | |
| Anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies, anti-extractable nuclear antigens, anti-CCP, cryoglobulins, anti-cardiolipin | Negative | Negative | ANA 1:100 |