Table 3.
Pooled OR (95% CI) for the association between paternal occupational exposures to paint and the risk of leukaemia in the offspring: Overall and by subgroups
| Paternal exposures around conception
|
|||
|---|---|---|---|
| Total N Case/Controls | % in High likelihood of exposure group | OR1,2, (95% CI) | |
| 1. ALL | |||
| Overall | 8185/14210 | 2.0/2.1 | 0.93 (0.76, 1.14) |
| Immunophenotype | |||
| B-lineage cases | 6457/14210 | 2.1/2.1 | 0.93 (0.75, 1.15) |
| T-lineage cases | 826/14210 | 2.1/1.7 | 0.80 (0.46,1.39) |
| Age at diagnosis | |||
| Less than 5 years | 4750/7826 | 2.3/2.1 | 1.05 (0.81, 1.36) |
| 5 or more years | 3435/6384 | 1.7/2.2 | 0.78 (0.56, 1.08) |
| Interaction p value = 0.45 | |||
| Sex | |||
| Girls | 3587/6276 | 2.0/2.1 | 0.97 (0.71, 1.31) |
| Boys | 4598/7934 | 2.0/2.1 | 0.90 (0.69, 1.18) |
| Interaction p value = 0.12 | |||
| Child’s birth year | |||
| Before 1996 | 5961/10385 | 2.0/2.1 | 0.88 (0.69, 1.11) |
| 1996 or later | 2224/3825 | 2.0/2.1 | 1.08 (0.74, 1.57) |
| Interaction p value =0.74 | |||
| Type of occupational assessment | |||
| Assessment based on expert assessment3 | 1114/1536 | 6.2/6.0 | 1.13 (0.81,1.58) |
| Assessment based on coded job titles4 | 6935/12384 | 1.3/1.4 | 0.87 (0.67,1.14) |
| Interaction p value =0.29 | |||
| 2. AML | |||
| Overall | 1231/11392 | 3.3/1.9 | 0.96 (0.65,1.41) |
| Age at diagnosis | |||
| Less than 5 years | 584/6118 | 3.3/1.8 | 0.96 (0.54, 1.73) |
| 5 or more years | 647/5274 | 3.4/2.0 | 0.90 (0.53,1.53) |
| Interaction p value = 0.68 | |||
| Sex | |||
| Girls | 588/5034 | 3.1/2.0 | 0.77 (0.43, 1.37) |
| Boys | 643/6358 | 3.6/1.8 | 1.17 (0.69, 1.98) |
| Interaction p value = 0.43 | |||
| Child’s birth year | |||
| Before 1996 | 1008/8235 | 3.8/2.2 | 0.96 (0.64, 1.44) |
| 1996 or later | 223/3157 | 1.3/1.0 | 1.21 (0.36, 4.11) |
| Interaction p value = 0.69 | |||
| Type of occupational assessment | |||
| Assessment not based on coded job titles5 | 482/808 | 6.0/8.0 | 0.96 (0.58, 1.59) |
| Assessment based on coded job titles6 | 749/10584 | 1.6/1.4 | 0.94 (0.52, 1.72) |
| Interaction p value = 0.46 | |||
OR comparing Group 1 (High likelihood of paint exposure) to reference group 4 (No or minimal likelihood of paint exposure)
Adjusted for age, sex, birth year group, study and paternal education
Australia (Aus-ALL), Canada.
France (ADELE & ESCALE), Greece (NARECHEM 1993–1994 & 1996–2011), Germany (GCCR), Italy (SETIL), UK (UKCCS), US (COG-E15) US, NCCLS. See Table 1 for details of the Occupational coding system.
New Zealand (NZCCS), US (COG (CCG-E14).
France (ADELE & ESCALE), Greece (NARECHEM 1993–1994 & 1996–2011), Germany (GCCR), Italy (SETIL), UK (UKCCS), US (COG-E14) US, NCCLS. See Table 1 for details of the Occupational coding system.