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. Author manuscript; available in PMC: 2016 Apr 26.
Published in final edited form as: Cell Rep. 2015 Dec 31;14(2):282–297. doi: 10.1016/j.celrep.2015.12.029

Figure 7. Increased HSV1γ34.5 oncolytic effect was observed in colon cancer cells with impaired STING signal in vivo.

Figure 7

(A) Scheme of HSV1γ34.5 treatment on xenograft tumor in nude mice. (B–D)The indicated xenograft tumors were generated in the right flank of nude Balb/c mice. When tumors had reached approximately 0.5 cm in diameter, tumors were injected every other day a total of three times (arrows) with 1E7 PFU HSV1γ34.5 in 50 μl PBS (N=7) or 50 μl PBS only (N=3) and tumor growth measured every other day. Data is representative of two independent experiments. Statistical analysis was carried out comparing the two treatment groups at the last time point using the unpaired Student’s t-test. P values are as indicated.