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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: Nature. 2016 Feb 3;530(7589):184–189. doi: 10.1038/nature16932

Extended Data Figure 5. Senescent cell clearance increases delays tumor and cataract formation.

Extended Data Figure 5

a, b, Survival curves of mixed (a) and C57BL/6 (b) ATTAC mice dying of cancer (mice that had an overt tumor at time of death; only mice with lymphomas, sarcomas and carcinomas were included). Median survival (in days) and percentage increase are indicated. c, d, Incidence of macroscopically detectable neoplasms (lymphomas, sarcomas and carcinomas) at time of death in mixed (c) and C57BL/6 (d) ATTAC mice from survival cohorts. e, Survival curves of C57BL/6-129Sv-FVB mice dying without cancer (mice that had an overt tumor at time of death, including lymphoma, sarcoma and/or carcinoma, were excluded). Median survival (in days) and percentage increase are indicated. f–g, Cataract incidence for mixed (f) and C57BL/6 (g) ATTAC mouse cohorts. Log-rank tests were used to determine statistical significance in a, b, and e–g. *, P<0.05; **, P<0.01; ***, P<0.001.