Extended Data Figure 7. Senescent cell clearance has no impact on hematological parameters and age-related changes in leukocyte populations.

a–l, Hematology results of 3-, and 10-month-old untreated ATTAC C57BL/6 mice and 18-month-old vehicle and AP treated ATTAC C57BL/6 mice. White blood cell count (a), platelet count (b), red blood cell count (c), hemaglobin concentration (d), haematocrit (e), mean corpuscular volume (f), mean corpuscular haemoglobin (g), neutrophils (h), lymphocyptes (i), basophils (j), monocytes (k), and eosinophils (l). (m–q), Assessment for leukocyte subpopulations in 3-, and 10-month-old untreated ATTAC C57BL/6 mice and 18-month-old vehicle and AP treated ATTAC C57BL/6 mice. CD4⁺ T cells (% of peripheral blood mononuclear cells or PBMC) (m), CD8⁺ T cells (% of PBMC) (n), CD44^hi CD4⁺ T cells (% of CD4⁺) (o), CD44^hi CD8⁺ T cells (% of CD8⁺) (p), and NK1.1⁺ cells (% of PBMC) (q). Key and animal numbers in b–l are as indicated in a, key and animal numbers in n–q are as indicated in m. Error bars indicate s.e.m. Unpaired two-tailed t tests were used to determine statistical significance. *, P<0.05; **, P<0.01; ***, P<0.001.