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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: Nature. 2016 Feb 3;530(7589):184–189. doi: 10.1038/nature16932

Figure 2. Senescent cell clearance extends lifespan.

Figure 2

a, Study design for clearance of senescent cells in mixed and C57BL/6 mouse cohorts. Healthspan analysis was done at 18 months, an age where relatively few mice in vehicle (Veh)- or AP-treated have died and bias due to selection for long-lived animals is unlikely. b, c, Survival curves for vehicle- (–AP) and AP-treated (+AP) mixed (b) and C57BL/6 mice (c). Median survival (in days) and percentage increase in median survival are indicated. We note that median lifespans of our vehicle-treated cohorts are similar to those of wild-type mice administered AP (c). Log-rank tests were used to determine statistical significance. *, P<0.05; **, P<0.01; ***, P<0.001.