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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: Nature. 2016 Feb 3;530(7589):184–189. doi: 10.1038/nature16932

Figure 3. Clearance of senescent cells prolongs healthspan.

Figure 3

a, Survival curves of AT-TAC mice dying of cancer (mice that had an overt tumor at time of death; mice with lymphomas, sarcomas and carcinomas were included, mice without tumors were censored). Median survival and percentage increase are indicated. b, Representative images of aged mice with and without senescent cell clearance. c, Spontaneous movement and exploratory behavior of ATTAC mice analyzed by the open field test. Error bars indicate s.e.m. Log-rank tests were used to determine statistical significance in a; unpaired two-tailed t tests were used in c. *, P<0.05; **, P<0.01; ***, P<0.001.