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. 2015 Oct 12;4(10):e002137. doi: 10.1161/JAHA.115.002137

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Forest plot showing the pooled difference between the mineralocorticoid receptor antagonist therapy group and the control group for changes in measures of collagen turnover (surrogate for myocardial fibrosis) from baseline to follow‐up. A, PIIINP; (B) PICP. Results are presented for the pooled analyses of all available studies as well as the subgroups of studies with HFPEF and asymptomatic diastolic dysfunction. CI, indicates confidence interval; HFPEF, heart failure with preserved ejection fraction; MRA, mineralocorticoid receptor antagonist; PICP, carboxy‐terminal peptide of procollagen type I; PIIINP, amino‐terminal peptide of procollagen type II.