Table 1.
Metabolites Detected
| Name | Precursor FA | Omega 6/3 | Enzyme | Lipid Map ID | HMDB ID |
|---|---|---|---|---|---|
| 12‐HETE | AA | n‐6 | 12‐LOX | LMFA03060088 | HMDB06111 |
| 15‐HETE | AA | n‐6 | 15‐LOX | LMFA03060001 | HMDB03876 |
| 8‐HETE | AA | n‐6 | 15‐LOX | LMFA03060006 | HMDB04679 |
| LTB4 | AA | n‐6 | 5‐LOX | LMFA03020001 | HMDB01085 |
| 5‐HETE | AA | n‐6 | 5‐LOX | LMFA03060002 | HMDB11134 |
| TXB2 | AA | n‐6 | COX | LMFA03030002 | HMDB03252 |
| PGF2α | AA | n‐6 | COX | LMFA03010002 | HMDB01139 |
| 13,14‐dihydro‐PGF2α | AA | n‐6 | COX | LMFA03010079 | HMDB04239 |
| 12S‐HHTrE | AA | n‐6 | COX | LMFA03050002 | HMDB12535 |
| 11‐HETE | AA | n‐6 | COX | LMFA03060028 | HMDB04682 |
| 14,15‐DiHETrE | AA | n‐6 | CYP | LMFA03050010 | HMDB02265 |
| 11,12‐DiHETrE | AA | n‐6 | CYP | LMFA03050008 | HMDB02314 |
| 8,9‐DiHETrE | AA | n‐6 | CYP | LMFA03050006 | HMDB02311 |
| 20‐HETE | AA | n‐6 | CYP | LMFA03060009 | HMDB05998 |
| 5,6‐DiHETrE | AA | n‐6 | CYP | LMFA03050004 | HMDB02343 |
| 9‐HOTrE | ALA | n‐3 | 5‐LOX | LMFA02000024 | HMDB10224 |
| 15(S)‐HETrE | DGLA | n‐6 | 15‐LOX | LMFA03050007 | HMDB05045 |
| PGF1α | DGLA | n‐6 | COX | LMFA03010137 | HMDB02685 |
| 19,20‐DiHDPA | DHA | n‐3 | CYP | LMFA04000043 | HMDB10214 |
| 12(S)‐HEPE | EPA | n‐3 | 12‐LOX | LMFA03070008 | HMDB10202 |
| 15(S)‐HEPE | EPA | n‐3 | 15‐LOX | LMFA03070009 | HMDB10209 |
| 5(S)‐HEPE | EPA | n‐3 | 5‐LOX | LMFA03070010 | HMDB05081 |
| 13‐HODE | LA | n‐6 | 15‐LOX | LMFA02000228 | HMDB06939 |
| 9‐HODE | LA | n‐6 | 5‐LOX | LMFA02000151 | HMDB10223 |
| 9‐KODE | LA | n‐6 | 5‐LOX | LMFA02000274 | HMDB04669 |
| 9,12,13‐TriHOME | LA | n‐6 | 5‐/15‐LOX | LMFA02000014 | HMDB04708 |
| 12,13‐DiHOME | LA | n‐6 | CYP | LMFA02000230 | HMDB04705 |
| 9,10‐DiHOME | LA | n‐6 | CYP | LMFA02000229 | HMDB04704 |
| 12(13)‐EpOME | LA | n‐6 | CYP | LMFA02000038 | HMDB04702 |
| 9(10)‐EpOME | LA | n‐6 | CYP | LMFA02000037 | HMDB04701 |
AA indicates arachidonic acid; ALA, α‐linolenic acid; COX, cyclooxygenase; CYP, cytochrome P450; DGLA, dihomo‐γ‐linolenic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FA, fatty acid; LA, linoleic acid; LOX, lipoxygenase.