Table 3.
Significant Oxylipid Differences in Women Versus Men
| Metabolites | Pre‐aspirin | Postaspirin | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Name | Precursor | Enzyme | Women | Men | P Value | Q | Women | Men | P value | Q |
| 5‐HEPE | EPA | 5‐LOX | 5.3±3.4 | 3.4±2.9 | 2×10−8 | 4×10−7 | 3.6±2.3 | 2.3±1.2 | 1×10−5 | 1.8×10−4 |
| 13‐HODE | LA | 15‐LOX | 24±10.5 | 18.3±8.7 | 3×10−5 | 3×10−4 | 17.2±7.3 | 14.2±7.8 | 2×10−5 | 1.8×10−4 |
| 9‐HODE | LA | 5‐LOX | 22.4±10.6 | 16.9±7.2 | 7×10−5 | 4×10−4 | 14.8±5.6 | 13.1±7 | 2×10−3 | 0.007 |
| 5,6‐DiHETrE | AA | CYP | 3.4±1.5 | 4.4±2 | 3×10−4 | 1.2×10−3 | 2.5±1.1 | 3.2±1.4 | 4×10−4 | 0.002 |
| 5‐HETE | AA | 5‐LOX | 15±6.6 | 12±5.4 | 2×10−3 | 6×10−3 | 11.5±5.7 | 9.2±4.5 | 3×10−3 | 0.008 |
| 9‐HOTrE | ALA | 5‐LOX | 1.1±0.6 | 0.8±0.4 | 4×10−3 | 0.01 | 0.7±0.4 | 0.6±0.4 | 0.25 | 0.2 |
| 9,10‐EpOME | LA | CYP | 3.3±1.6 | 2.7±2.6 | 2×10−4 | 0.001 | 2.6±2 | 2.3±2 | 0.2 | 0.2 |
| 12;13‐DiHOME | LA | CYP | 12.7±5.6 | 10.7±6.3 | 3×10−3 | 0.008 | 11.3±6.2 | 9.3±4.9 | 3×10−3 | 0.008 |
| 11,12‐DiHETrE | AA | CYP | 3.7±1.3 | 3.2±1 | 0.01 | 0.02 | 3±0.9 | 2.8±0.9 | 0.04 | 0.06 |
Data represent mean±SD of metabolite concentrations (nmol/L) in men (n=75) and women (n=81). AA indicates arachidonic acid; ALA, α‐linolenic acid; CYP, cytochrome P450; EPA, eicosapentaenoic acid; LA, linoleic acid; LOX, lipoxygenase.