Table 3.

Models of Multiple Regression Analysis Testing the Variability of ARD‐z Compared With Stroke Volume, Heart Rate, Diastolic Blood Pressure and Pulse Pressure

	Model 1 (Multiple R=0.35)			Model 2 (Multiple R=0.38)
	Standardized Coefficients β	P Value	Variance Inflation Factor	Standardized Coefficients β	P Value	Variance Inflation Factor
Age, y	−0.07	<0.0006	1.37	−0.10	<0.0001	1.69
Female sex	0.14	<0.0001	1.20	0.10	<0.009	4.01
Stroke volume, mL/beat	0.31	<0.0001	1.22	0.25	<0.0001	1.58
Cuff pulse pressure, mm Hg	−0.11	<0.0001	1.37	−0.10	<0.0001	1.38
Cuff diastolic BP, mm Hg	0.10	<0.0001	1.16	0.09	<0.0001	1.25
Heart rate, bpm	0.08	<0.0001	1.07	0.04	<0.02	1.17
Degree of relatednessa	−0.05	<0.0513	1.75	−0.05	<0.03	1.77
Body fat, kg	—	—	—	0.01	<0.79	6.21
Fat‐free mass, kg	—	—	—	−0.01	<0.79	5.01
Waist circumference, cm	—	—	—	0.12	<0.01	6.60
White blood cell count, 109/L	—	—	—	−0.03	<0.23	1.35
Neutrophils, %	—	—	—	0.07	<0.001	1.24
C‐reactive protein, mg/L	—	—	—	−0.01	<0.58	1.46
Plasma fibrinogen, mg/dL	—	—	—	0.03	<0.18	1.77
PAI‐1, ng/mL	—	—	—	0.05	<0.01	1.24
Triglycerides, mg/dL	—	—	—	0.03	<0.17	1.32
Total cholesterol, mg/dL	—	—	—	−0.02	<0.31	1.37

In Model 1, the 4 hemodynamic components were entered; in Model 2, parameters of body fatness and inflammation were forced. ARD‐z indicates sex‐specific z score for measured and predicted aortic root dimension values; BP, blood pressure; PAI‐1, plasminogen activator inhibitor‐1.

^aRelatedness was evaluated by standard kinship coefficients (0.25 for parent/offspring, 0.25 for full siblings, 0.125 for half siblings, and 0 for no consanguinity).29