Table 4.

Models of Multiple Regression Analysis Testing the Variability of ARD‐z Compared With Stroke Volume, Heart Rate, Central Diastolic Blood Pressure and Central Pulse Pressure Estimated by Applanation Tonometry

	Model 1 (Multiple R=0.35)			Model 2 (Multiple R=0.38)
	Standardized Coefficients β	P Value	Variance Inflation Factor	Standardized Coefficients β	P Value	Variance Inflation Factor
Age, y	−0.08	<0.002	1.53	−0.11	<0.0002	1.87
Female sex	0.15	<0.0001	1.18	0.11	<0.009	3.98
Stroke volume, mL/beat	0.31	<0.0001	1.23	0.25	<0.0001	1.56
Central pulse pressure, mm Hg	−0.09	<0.001	1.64	−0.09	<0.0009	1.66
Central diastolic BP, mm Hg	0.10	<0.0001	1.11	0.08	<0.0004	1.19
Heart rate, bpm	0.05	<0.02	1.09	0.02	<0.40	1.18
Degree of relatednessa	−0.03	<0.30	1.65	−0.03	<0.21	1.68
Body fat, kg	—	—	—	0.01	<0.85	5.59
Fat‐free mass, kg	—	—	—	−0.02	<0.69	5.10
Waist circumference, cm	—	—	—	0.13	<0.02	6.28
White blood cell count, 109/L	—	—	—	−0.02	<0.36	1.34
Neutrophils, %	—	—	—	0.07	<0.003	1.24
C‐reactive protein, mg/L	—	—	—	−0.01	<0.57	1.47
Plasma fibrinogen, mg/dL	—	—	—	0.03	<0.2501	1.74
PAI‐1, ng/mL	—	—	—	0.05	<0.0353	1.24
Triglycerides, mg/dL	—	—	—	0.03	<0.1786	1.31
Total cholesterol, mg/dL	—	—	—	−0.02	<0.4864	1.32

In Model 1, the 4 hemodynamic components were entered; in Model 2, parameters of body fatness and inflammation were forced. ARD‐z indicates sex‐specific z score for measured and predicted aortic root dimension values; BP, blood pressure; PAI‐1, plasminogen activator inhibitor‐1.

^aRelatedness was evaluated by standard kinship coefficients (0.25 for parent/offspring, 0.25 for full siblings, 0.125 for half siblings, and 0 for no consanguinity).29