Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 27;4(10):e002254. doi: 10.1161/JAHA.115.002254

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Representative histology of atherosclerotic lesions in the coronary arteries of adult RFH swine. A, Hematoxylin and eosin (H&E) staining and Movat's Pentachrome revealed wall thickening, fibrin accumulation, and plaque buildup in coronary arteries. B, α‐SMA‐positive cells were detected in the subendothelial region. C, Lipid oxidation was observed by immunostaining of oxApoB and malondialdehyde. D, Apoptotic cells were identified throughout the arteries by immunostaining for caspase 3. E, Leukocyte degranulation (CD107a) and the secretion of MCP‐1 were also observed in the intima, as expected in an atherosclerotic plaque. Scale bars: 400 μm (A and C); 200 μm (B, D, and E). Arrows indicate areas representative of positive staining. N=4 animals. MCP‐1 indicates monocyte chemoattractant protein‐1; oxApoB, oxidatively modified apolipoprotein B; RFH, Rapacz familial hypercholesterolemic; α‐SMA, alpha‐smooth muscle actin.