Figure 10.

Cardiac MCP‐3 expression is upregulated in Mmp2 ^−/− mice and unrelated to systemic secreted phospholipase A₂ activity. A, MCP‐3 protein levels in the heart, plasma, and liver of mice administered nMCP‐3 Ab or isotype‐matched IgG₁ (0.6 mg/kg per day). Results are representative of 19 to 20 mice per genotype (n=3 to 4 mice per time point). *P≤0.05 vs WT at day 0. ^† P≤0.05 vs Mmp2 ^−/− plus IgG₁ at day 5. Note that the data presented for day 2.5 refer to pools of 3 to 4 mice for which MCP‐3 levels were measured in duplicate; for simplicity, no statistical analysis is indicated at day 2.5. B, MCP‐3 protein levels in the heart, plasma, and liver of mice administered varespladib (10 mg/kg per day). Results are representative of 12 to 13 mice per genotype (3 to 5 mice per time point were pooled and MCP‐3 levels were measured in duplicate). *P≤0.05 vs WT at day 0. ^† P≤0.05 vs Mmp2 ^−/− at day 5. MCP‐3 indicates monocyte chemoattractant protein 3; nMCP‐3 Ab, neutralizing MCP‐3 monoclonal antibody; WT, wild type.