Table 3.
Association of N‐glycome Structures with SBIs in the Multivariate Analysis
| Variables | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Age per 1‐year increase | 1.09 (1.05–1.14) | 1.08 (1.03–1.13) | 1.08 (1.03–1.13) |
| Sex, male | 2.84 (1.77–4.57) | 2.61 (1.58–4.32) | 2.5 (1.46–4.28) |
| Mean office DBP per 1 mm Hg increase | 1.03 (1.00–1.05) | ns | 1.3 (1.00–1.05) |
| Microalbuminuria | — | 2.50 (1.45–4.31) | 1.87 (1.04–3.36) |
| NA2F≥16.657 | — | — | 0.42 (0.26–0.69) |
| NA3Fb>2.1134 | — | — | 1.81 (1.00–3.28) |
Model 1 is adjusted by age, sex, mean (DBP), diabetes, tobacco, and high‐density lipoprotein cholesterol. Model 2 is additionally adjusted by microalbuminuria and lipoprotein‐associated phospholipase A2 activity nmol/mL per minute. Model 3 includes the same covariates as model 2 plus the relative amounts of NA2F and NA3Fb below and above their calculated cutoffs. ns, means office DBP was not included in model 2. DBP indicates diastolic blood pressure; NA2F, peak 6, to bigalacto core‐α‐1,6‐fucosylated biantennary glycan; NA3Fb, peak 9, to branching α‐1,3‐fucosylated triantennary glycan; OR, odds ratio; SBI, silent brain infarct.