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. 2014 Nov 3;3(1):e965642. doi: 10.4161/23723548.2014.965642

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Schematic showing how iron metabolism might regulate p53 signaling and tumorigenesis. Heme directly binds to p53 protein and downregulates p53 signaling by interfering with p53–DNA interaction and promoting nuclear export of p53 and its subsequent cytosolic proteolysis. p53 refers to tumor suppressor p53 (TP53); CRM1, chromosomal region maintenance 1/exportin 1; Ub, ubiquitin.