. 2015 Dec 16;4(12):e002346. doi: 10.1161/JAHA.115.002346

Table 4.

Relation Between Classical Cardiovascular Risk Factors and Chemokines (n=124)

	MCP‐1 (ng/mL)^a	P Value	RANTES (ng/mL)^a	P Value	VCAM (ng/mL)^a	P Value	ICAM (ng/mL)^a	P Value
Age, y
Crude model^b	−0.01 (−0.02, 0.01)	0.25	4.71 (1.11, 8.44)	0.01^c	15.49 (8.87, 22.51)	<0.001^c	−3.25 (−7.23, 0.80)	0.12
Model 1^b	−0.01 (−0.02, 0.01)	0.23	4.81 (1.21, 8.44)	0.01^c	15.49 (8.87, 22.51)	<0.001^c	−3.25 (−7.23, 0.90)	0.34
Model 2^b	−3.00×10⁻³ (−0.02, 0.01)	0.66	5.33 (1.41, 9.31)	0.01^c	15.14 (7.68, 17.12)	<0.001^c	−2.66 (−6.85, 1.61)	0.21
Sex (ref: female)
Crude model^b	0.02 (−0.01, 0.05)	0.26	−8.61 (−14.87, −1.88)	0.01^c	1.31 (−10.95, 15.14)	0.85	−3.92 (−12.19, 4.08)	0.33
Model 1^b	0.02 (−0.01, 0.05)	0.26	−8.61 (−14.87, −1.88)	0.01^c	1.31 (−10.95, 15.14)	0.85	−3.92 (−12.19, 4.08)	0.33
Model 2^b	0.02 (−0.01, 0.05)	0.25	−6.57 (−13.67, 1.01)	0.09	1.21 (−12.63, 17.23)	0.87	0.20 (−8.33, 9.41)	0.97
BMI, kg/m²
Crude model^b	−0.01 (−0.02, 0.01)	0.24	−0.60 (−4.11, 3.05)	0.72	5.34 (−1.09, 12.19)	0.10	2.02 (−2.27, 6.29)	0.38
Model 1^b	−0.01 (−0.02, 0.01)	0.23	−0.60 (−4.02, 3.05)	0.75	5.34 (−1.09, 12.19)	0.10	1.92 (−2.27, 6.29)	0.37
Model 2^b	−0.01 (−0.03, 0.01)	0.51	−0.80 (−5.35, 3.98)	0.74	4.29 (−4.40, 13.88)	0.34	1.51 (−3.63, 7.04)	0.56
SBP, mm Hg
Crude model^b	−0.01 (−0.02, 4.00×10⁻³)	0.17	−1.09 (−4.59, 2.53)	0.55	2.63 (−3.63, 9.42)	0.41	2.53 (−1.69, 6.93)	0.24
Model 1^b	−0.01 (−0.02, 4.60×10⁻³)	0.18	−1.19 (−4.59, 2.33)	0.50	2.63 (−3.63, 9.42)	0.41	2.53 (−1.69, 6.93)	0.25
Model 2^b	−4.00×10⁻³ (−0.02, 0.01)	0.61	−1.49 (−5.35, 2.43)	0.45	0.30 (−6.85, 8.00)	0.94	1.61 (−2.76, 6.29)	0.47
HDL cholesterol, mmol/L
Crude model^b	2.00×10⁻³ (−0.01, 0.02)	0.77	−1.19 (−4.78, 2.53)	0.54	−3.05 (−9.52, 3.77)	0.37	−3.54 (−7.50, 0.60)	0.10
Model 1^b	1.00×10⁻³ (−0.01, 0.02)	0.91	−0.60 (−4.21, 3.15)	0.74	−3.25 (−9.70, 3.77)	0.35	−3.34 (−7.41, 0.80)	0.11
Model 2^b	−2.00×10⁻³ (−0.02, 0.02)	0.83	−1.88 (−5.82, 2.33)	0.37	−2.27 (−9.52, 5.65)	0.56	−2.66 (−7.13, 2.02)	0.25
LDL cholesterol, mmol/L
Crude model^b	4.00×10⁻³ (−0.01, 0.02)	0.60	1.31 (−2.37, 5.23)	0.48	−0.40 (−7.13, 6.82)	0.91	4.60 (0.20, 9.09)	0.04^c
Model 1^b	4.85×10⁻³ (−0.01, 0.02)	0.52	1.11 (−2.66, 4.92)	0.58	−0.40 (−7.13, 6.93	0.92	4.50 (0.10, 8.98)	0.04^c
Model 2^b	0.01 (−0.01, 0.02)	0.38	1.21 (−2.86, 5.34)	0.57	−0.60 (−7.78, 7.14)	0.88	3.36 (−1.19, 8.22)	0.15
Triglycerides, mmol/L
Crude model^b	−0.01 (−0.03, 4.00×10⁻³)	0.14	−0.02 (−3.63, 3.77)	0.99	2.02 (−4.78, 9.31)	0.56	5.44 (1.11, 9.97)	0.01^c
Model 1^b	−0.01 (−0.03, 4.56×10⁻³)	0.17	−0.40 (−4.02, 3.36)	0.82	2.12 (−4.69, 9.53)	0.55	5.34 (1.01, 9.86)	0.02^c
Model 2^b	−0.01 (−0.03, 0.01)	0.31	−0.60 (−4.69, 3.56)	0.76	0.50 (−6.94, 8.65)	0.89	4.92 (0.20, 9.97)	0.04^c
HOMA‐IR
Crude model^b	−4.00×10⁻³ (−0.02, 0.01)	0.62	−0.10 (−3.73, 3.67)	0.97	7.25 (0.20, 14.91)	0.04^c	2.63 (−1.78, 7.14)	0.25
Model 1^b	−4.00×10⁻³ (−0.02, 0.01)	0.63	−0.10 (−3.73, 3.56)	0.94	7.25 (0.20, 14.91)	0.04^c	2.53 (−1.78, 5.65)	0.25
Model 2^b	−1.47×10⁻⁴ (−0.02, 0.02)	0.99	0.04 (−4.50, 4.81)	0.99	4.50 (−4.21, 14.11)	0.32	−0.30 (−5.35, 5.13)	0.92

BMI indicates body mass index; HDL, high‐density lipoprotein; HOMA‐IR, homeostasis model assessment of insulin resistance; ICAM, intracellular adhesion molecule; LDL, low‐density lipoprotein; MCP‐1, monocyte chemotactic protein 1; RANTES, regulated on activation normal T‐cell expressed and secreted; SBP, systolic blood pressure; VCAM, vascular cell adhesion molecule.

Values are regression coefficients per 1 SD increase in CV risk factor level with 95% confidence intervals.

Crude model, model 1: adjusted for sex; model 2: adjusted for sex, SBP, BMI, LDL‐cholesterol level, HDL‐cholesterol level, triglyceride level and HOMA‐IR.

P<0.05.