Table 3.
Univariate and Multivariable Cox Regression Models for All HRT Recipients
| Univariate Cox Models | Final Multivariable Model | |||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | P Value | Hazard Ratio | 95% CI | P Value | |
| Heart retransplant | ||||||
| With concurrent KT (HRT‐KT) | 0.63 | 0.45–0.87 | 0.006 | 0.50 | 0.33–0.76 | 0.001 |
| Without KT (HRT alone) | 1.00 | — | — | 1.00 | — | — |
| Recipient age | 1.01 | 1.00–1.01 | <0.001 | |||
| Status 1A | 1.61 | 1.39–1.87 | <0.001 | 1.28 | 1.04–1.58 | 0.021 |
| Days spent on wait‐list | 1.00 | 1.00–1.00 | 0.036 | |||
| Years since first transplant | 0.94 | 0.92–0.95 | <0.001 | 0.98 | 0.95–1.00 | 0.032 |
| eGFR <30 or on dialysis | 1.69 | 1.41–2.02 | <0.001 | 1.87 | 1.53–2.30 | <0.001 |
| ECMO support | 2.62 | 1.87–3.66 | <0.001 | 1.89 | 1.15–3.12 | 0.013 |
| Mechanical ventilation | 1.87 | 1.55–2.25 | <0.001 | |||
| Donor age | 1.01 | 1.00–1.01 | 0.001 | 1.01 | 1.01–1.02 | 0.001 |
| Donor inotrope use | 0.70 | 0.59–0.82 | <0.001 | |||
| Heart ischemic time | 1.07 | 1.01–1.14 | 0.032 | 1.18 | 1.09–1.28 | <0.001 |
| Era of heart retransplant | ||||||
| 1987–1995 | 1.00 | — | — | 1.00 | — | — |
| 1996–2000 | 0.65 | 0.55–0.78 | <0.001 | 0.68 | 0.53–0.88 | 0.003 |
| 2001–2005 | 0.51 | 0.42–0.62 | <0.001 | 0.53 | 0.40–0.70 | <0.001 |
| 2006–2011 | 0.47 | 0.38–0.59 | <0.001 | 0.57 | 0.42–0.78 | 0.001 |
All variables included in this table had univariate P<0.10 and were considered for the preliminary multivariable model. The final multivariable model was reduced to all variables with P<0.05. ECMO indicates extracorporeal membrane oxygenation; eGFR, estimated glomerular filtration rate; HRT, heart retransplant; KT, kidney transplant; Status 1A, highest wait‐list urgency status.