Figure 1.

To identify a pathogenic mutation among variants identified by whole exome sequencing, an iterative filtering scheme was employed. Twelve rare coding variants in 8 genes fit plausible modes of inheritance for sporadic DCM. Of the 12 variants (Table S1), only 3 variants in 2 candidate genes, TNNT2 and XIRP2, fit >1 of the following criteria: showed striated muscle enrichment; had an associated cardiac phenotype in mice; and/or were located within 1 node of a known DCM gene. 1000G indicates 1000 genomes; CG, complete genomics; DCM, dilated cardiomyopathy; EVS, exome variant server; MAF, minor allele frequency.