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. 2015 Nov 26;4(12):e002426. doi: 10.1161/JAHA.115.002426

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Morphological findings of peri‐adventitial nerves. In patients in the DIAL group, a significant increase in nerve density in the internal area of the peri‐adventitial tissue (within the first 0.5 mm from the beginning of adventitia) was observed (A, NF stain—×2 and B, ×4) compared with the CTRL group (C, NF stain—×2). The efferent nerve fibers (D, tyrosine hydroxylase stain—×20) were more numerous than afferent fibers (E, calcitonin gene–related peptide stain—×20; F, Detail of area delimited by the rectangle in D, ×40). CTRL indicates control; DIAL, dialysis; NF, neurofilament protein.